Population
Renal cortical tubules and immortalized renal proximal tubule cells from normotensive Wistar-Kyoto rats and…
Comparison
Fenoldopam (D1-like agonist) vs Untreated cells or cells treated with SCH23390
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for PP2A in D1 receptor dysfunction in genetic hypertension models.
Differential regulation of renal PP2A activity by D1-like receptors in SHR versus WKY rats may explain the hyperphosphorylation and desensitization of the D1 receptor in genetic hypertension.
Yu et al. (2000) studied this question.
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