Phase‐contrast MRI‐based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall
Why the study?
Can phase-contrast MRI-based elastography detect early hypertensive changes in ex vivo porcine aortas?
Population
10 female domestic pigs, randomized to normal control or renovascular hypertension for 3 months.
Comparison
Phase-contrast MRI-based elastography technique vs Normal control aortas vs hypertensive aortas
Design
Preclinical, randomized to a normal control group or a renovascular…
Follow-up
3 months
Authors
Discussion
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Member takes
Implication
May support MRI elastography for early aortic stiffness; leaves open human translation and clinical adoption.
Structured PICO
Can phase-contrast MRI-based elastography detect early hypertensive changes in ex vivo porcine aortas?
P
Population
10 female domestic pigs (ex vivo abdominal aortas), randomized to normal control (n=5) or renovascular hypertension (n=5) for 3 months.
I
Intervention
Phase-contrast MRI-based elastography technique
C
Comparator
Normal control aortas vs hypertensive aortas
O
Outcome
Young's modulus-wall thickness product (vascular stiffness)surrogate
Phase-contrast MRI-based elastography can detect early vascular stiffness changes secondary to hypertension in an ex vivo porcine model.
Cite This Study
Woodrum et al. (2009) studied this question.