Population
Chronic 2-kidney, 1 clip (2K1C) hypertensive rats at 6 months and 10 months after clipping
Comparison
Intracerebroventricular injections of antisense… vs Sense ODN, inverted ODN, saline, or intravenous…
Design
Preclinical
Follow-up
3 days
Authors
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Supports central RAS inhibition in hypertension models; leaves open translation to human therapy.
Inhibition of the brain renin-angiotensin system using antisense oligonucleotides significantly reduces systolic blood pressure in a chronic rat model of renovascular hypertension.
Kagiyama et al. (2001) studied this question.
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