Why the study?
Does AS-ODN targeted to AT1 mRNA reduce blood pressure in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and Sprague-Dawley rats
Comparison
Single dose of antisense oligodeoxynucleotides… vs Scrambled ODN injected intracerebroventricularly
Design
Preclinical
Follow-up
up to 9 days
Authors
Loading...
Provides proof-of-concept for central AT1 antisense in rat hypertension; leaves open human translation.
Does AS-ODN targeted to AT1 mRNA reduce blood pressure in spontaneously hypertensive rats?
A single central injection of AS-ODN targeted to AT1 receptor mRNA significantly reduces blood pressure for up to 7 days in spontaneously hypertensive rats.
Robert Gyurko (1997) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: