Key result
Antisense oligodeoxynucleotides to AGT mRNA and AT1 receptor mRNA significantly reduced systolic blood pressure by up to 41+/-10 mm Hg in rats with cold-induced hypertension.
Why the study?
Does antisense oligodeoxynucleotide inhibition of AGT or AT1 receptor mRNA reduce blood pressure in cold-induced hypertensive rats?
Population
Sprague-Dawley rats made hypertensive by chronic exposure to mild cold (5 degrees C/41 degrees F) (n=18)
Design
Preclinical
Follow-up
up to 7 days
Authors
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Cold-induced hypertension in rats engages multi-compartment RAS; leaves open relevance to human environmental hypertension.
Does antisense oligodeoxynucleotide inhibition of AGT or AT1 receptor mRNA reduce blood pressure in cold-induced hypertensive rats?
Mean Difference: -40
p-value: p=<0.01
Antisense oligodeoxynucleotides targeting the renin-angiotensin system effectively reduce blood pressure in a rat model of cold-induced hypertension, highlighting the role of both central and peripheral RAS in this model.
Peng et al. (1998) studied Cold-induced hypertension (n=18). Antisense oligodeoxynucleotides (AS-ODN) to AGT mRNA or AT1 receptor mRNA vs. Preinjection baseline was evaluated on Systolic blood pressure (40+/-6 mm Hg decrease, p=<0.01). Antisense oligodeoxynucleotides to AGT mRNA and AT1 receptor mRNA significantly reduced systolic blood pressure by up to 41+/-10 mm Hg in rats with cold-induced hypertension.
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