February 1, 2003Hypertension
Guanylyl Cyclase Receptors Mediate Cardiopulmonary Vagal Reflex Actions of ANP
Why the study?
Does pGC receptor antagonism block ANP-induced enhancement of cardiopulmonary vagal reflexes in rats?
Population
Conscious, chronically instrumented rats (n=9)
Comparison
Randomized infusions of rat ANP, the pGC… vs Saline infusion (270 micro L/h IV)
Design
Preclinical, Randomized infusions
Authors
Discussion
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Member takes
Implication
Supports pGC mediation of ANP reflex effects in rats; hypothesis-generating and should not yet influence clinical practice.
Structured PICO
Does pGC receptor antagonism block ANP-induced enhancement of cardiopulmonary vagal reflexes in rats?
P
Population
Conscious, chronically instrumented rats (n=9)
I
Intervention
Randomized infusions of rat ANP (150 ng/kg per minute IV), the pGC receptor antagonist HS-142-1 (3 mg/kg IV), or combined HS-142-1+ANP treatment
C
Comparator
Saline infusion (270 micro L/h IV)
O
Outcome
Cardiopulmonary baroreceptor reflex function (bradycardic responses to ramp blood pressure rises) and Bezold-Jarisch (B-J) reflex (evoked by serotonin)surrogate
The cardiopulmonary vagal reflex actions of ANP occur through pGC natriuretic peptide receptors, which are also essential for the full expression of the Bezold-Jarisch reflex.
Cite This Study
Thomas et al. (2003) studied this question.