March 1, 1989AJP Heart and Circulatory Physiology

Effects of dextran-induced hyperviscosity on regional blood flow and hemodynamics in dogs

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Population

10 pentobarbitalized dogs

Design

Preclinical

Authors

RCR. Y. ChenColumbia University RCRonald CarlinColumbia University SSShlomoh SimchonPulmonary Hypertension Association

Discussion

Member takes

Implication

Animal findings indicate organ-specific flow preservation via reduced vascular hindrance; leaves open applicability to clinical hyperviscosity states.

Structured PICO

Population

10 pentobarbitalized dogs

Intervention

Two steps of exchange transfusion of 200 ml of plasma with plasma containing high molecular weight dextran (mol wt 500,000, 20% wt/vol)

Outcome

Regional blood flow (measured by 15-microns microspheres) and vascular hindrancesurrogate

Dextran-induced hyperviscosity leads to compensatory vasodilation in several vital organs, serving to maintain blood flow and nutrient transport.

Cite This Study

Chen et al. (1989) studied this question.

synapsesocial.com/papers/6a7cacb2f40403d04c3f6fbe https://doi.org/10.1152/ajpheart.1989.256.3.h898

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Implication

Animal findings indicate organ-specific flow preservation via reduced vascular hindrance; leaves open applicability to clinical hyperviscosity states.

Effects of dextran-induced hyperviscosity on regional blood flow and hemodynamics in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of dextran-induced hyperviscosity on regional blood flow and hemodynamics in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider