Why the study?
Does rapid infusion of dextran 40 affect cardiac contractility in anesthetized dogs?
Population
5 pentobarbital-anesthetized dogs with autonomous nervous activity blocked with atropine and propranolol
Design
Preclinical
Authors
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Does not support clinical dextran use; leaves open translation of ventricular function effects to human models.
Does rapid infusion of dextran 40 affect cardiac contractility in anesthetized dogs?
Rapid infusion of hyperoncotic dextran 40 in dogs does not depress cardiac contractility and may improve ventricular function, possibly due to decreased aortic impedance.
K Pávek (1973) studied this question.
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