Why the study?
Viruses are an underappreciated cause of heart failure, and understanding shared and unique mechanisms of viral cardiac compromise is critical to inform therapeutic interventions.
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Design
Review
This review highlights the mechanisms of virus-induced cardiomyopathy, emphasizing the roles of direct viral damage and indirect immune responses like cytokine storms.
Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the key viruses known to lead to cardiac dysfunction operate. Both direct host-damaging mechanisms and indirect actions on the immune systems are discussed. As viral myocarditis is a key pathologic driver of heart failure in infected individuals, this review also highlights the role of cytokine storms and inflammation in virus-induced cardiomyopathy.
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Martens et al. (2021) studied this question.
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