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January 13, 2023EP EuropaceOpen Access

Outcome and safety of intraoperative defibrillation testing during device replacement: the Simpler trial

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Why the study?

Older registries showed an increased incidence of significant findings during defibrillation testing at replacement, leaving its frequency of significant findings and safety uncertain.

Does intraoperative defibrillation testing provide clinically important information or cause complications in patients undergoing ICD generator replacement?

Population

92 patients undergoing ICD generator replacement

Comparison

Defibrillation testing during ICD generator replacement

Design

Prospective observational multi-centre study

Follow-up

6-months post-procedure

Authors

AMAnat MilmanNational Archives and Records AdministrationENEyal NofElectrophysiologyMRMoshe RavElectrophysiology

Discussion

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Implication

DT during ICD replacement appears safe with low yield; leaves open whether routine testing should be abandoned pending larger studies.

Structured PICO

Does intraoperative defibrillation testing provide clinically important information or cause complications in patients undergoing ICD generator replacement?

P
Population
92 patients undergoing ICD generator replacement, median age 68 years, 79.8% male.
I
Intervention
Intraoperative defibrillation testing (DT) during ICD generator replacement
O
Outcome
Failure to terminate induced ventricular fibrillation (VF) with a single shock 10 J below the maximal capacity of the devicesurrogate

Intraoperative defibrillation testing during ICD generator replacement is safe but does not yield clinically important information, supporting the trend to abandon this practice.

Cite This Study

Milman et al. (2023) studied this question.

synapsesocial.com/papers/6a7cb41498c0e0ecb2770e01https://doi.org/10.1093/europace/euac282

Topics

Cardiac device therapy
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