Why the study?
Does intra-coronary implantation of nonmobilized peripheral-blood CD34+ cells result in successful myocardial homing in patients with acute myocardial infarction?
Does intra-coronary implantation of nonmobilized peripheral-blood CD34+ cells result in successful myocardial homing in patients with acute myocardial infarction?
Intracoronary injection of nonmobilized peripheral-blood CD34+ cells is feasible and results in detectable myocardial homing at 1 hour without acute restenosis or arrhythmia in AMI patients.
Feasible without acute safety signals in this case; leaves open therapeutic potential of CD34+ cells in AMI.
Granulocyte--colony-stimulating factor administered for autologous hematopoietic stem cell isolation from blood may favor restenosis in patients implanted after acute myocardial infarction (AMI). We therefore tested the isolation of peripheral-blood CD34+ cells without mobilization in six patients with AMI. After large-volume cytapheresis and positive CD34+ cell selection, 3.6 to 27.6 million CD34+ cells were obtained. We performed intra-coronary implantation of these cells and recorded no restenosis or arrhythmia. We used positron emission tomography (PET) to assess myocardial-labeled CD34+ cell homing, which accounted for 5.5% of injected cells 1 hour after implantation. In conclusion, large amounts of CD34+ cells, in the range reported in previous studies, can be obtained from nonmobilized peripheral blood. PET with [18F]-fluorodeoxyglucose cell labeling is an efficient imaging method for homing assessment.
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Blocklet et al. (2005) studied this question.
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