Population
Animal model of skeletal muscle disuse
Comparison
4 weeks of skeletal muscle disuse produced with… vs Respective control muscles
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypothesis-generating for fiber-specific oxidative decline in disuse; leaves open translation to human immobilization.
Immobilization leads to a decreased aerobic capacity specifically in muscle fibers with high oxidative enzyme activity.
Booth et al. (1973) studied this question.
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