What question did this study set out to answer?

To establish and evaluate a simplified surgical technique for producing experimental hypertension in rats by ligating the aorta between the renal arteries.

November 1, 1968Canadian Journal of Physiology and Pharmacology

A method for production of experimental hypertension in rats

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Authors

JRJ. M. Rojo-OrtegaUniversidad de Oviedo JGJacques GenestMedical Council of Canada

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Implication

May enable reproducible rat models for hypertension research; leaves open translation and validation in humans.

Key Points

To establish and evaluate a simplified surgical technique for producing experimental hypertension in rats by ligating the aorta between the renal arteries.
Performed complete surgical ligature of the abdominal aorta located between the origins of the renal arteries in rats across varying body weights.
Assessed the incidence of left kidney atrophy and subsequent hypertension across weight categories, contrasting rats under 150 g with those over 300 g.
Left kidney atrophy developed in approximately 90% of rats weighing over 300 g, but occurred almost never in rats weighing under 150 g.
Hypertension developed in the vast majority of rats weighing more than 300 g that exhibited an atrophic left kidney following aortic ligature.

Cite This Study

Rojo-Ortega et al. (1968) studied this question.

synapsesocial.com/papers/6a7cc327273accedbda8b39c https://doi.org/10.1139/y68-137

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A method for production of experimental hypertension in rats

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Implication

Key Points

Cite This Study

A method for production of experimental hypertension in rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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