Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II

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Structured PICO

Population

Ex vivo cultures of peritoneal cells from wild type mice, heparin-deficient mice, and mouse mast cell protease 4 (mMCP-4) knockout mice

Intervention

Addition of Angiotensin I (Ang I) and/or carboxypeptidase A (CPA) inhibitor

Comparator

Wild type cells or cells without CPA inhibitor

Outcome

Generation and degradation of Angiotensin II and other metabolitessurrogate

Mast cell chymase and carboxypeptidase A play key roles in the non-ACE-dependent generation and degradation of Angiotensin II.

Authors

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Does not alter ACE inhibitor use; leaves open mast cell chymase/CPA targeting in Ang II pathways pending in vivo and human studies.

Lundequist et al. (2004) studied this question.

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