Why the study?
Does genetic deletion of p47phox reduce atherosclerotic lesion formation in ApoE-/- mice?
Population
Genetically modified mice and smooth muscle cells from wild-type, p47phox-/-, and gp91phox-/- mice
Comparison
Genetic deletion of p47phox vs ApoE-/- mice with intact p47phox
Design
Preclinical
Authors
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Implicates NADPH oxidase in murine atherogenesis; leaves open whether p47phox targeting merits human investigation.
Does genetic deletion of p47phox reduce atherosclerotic lesion formation in ApoE-/- mice?
Genetic deletion of p47phox reduces atherosclerotic lesion formation in ApoE-/- mice, demonstrating a requisite role for NADPH oxidase-derived superoxide in atherosclerosis progression.
Barry-Lane et al. (2001) studied this question.
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