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October 1, 2004Acta Biochimica et Biophysica Sinica

NO Level and Endothelial NO Synthase Gene Polymorphism (Glu298Asp) in the Patients with Coronary Artery Disease from the Turkish Population

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Why the study?

Is there an association between eNOS Glu298Asp gene polymorphism, serum nitric oxide levels, and coronary artery disease in the Turkish population?

Population

400 Turkish individuals, including 250 patients with angiographically diagnosed coronary artery disease and…

Design

Case-control

Authors

LALale AfrasyapYahoo (Spain)GÖGüler ÖztürkIstanbul Medeniyet University

Discussion

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Member takes

Overview

No association found in Turkish cohort; leaves open eNOS Glu298Asp relevance to CAD in other populations.

Structured PICO

Is there an association between eNOS Glu298Asp gene polymorphism, serum nitric oxide levels, and coronary artery disease in the Turkish population?

P
Population
400 Turkish individuals, including 250 patients with angiographically diagnosed coronary artery disease (mean age 63.47 +/- 9.10 years) and 150 control subjects without any history and/or risk factors of coronary artery disease (mean age 60.71 +/- 9.14 years).
C
Comparator
Control subjects without coronary artery disease
O
Outcome
eNOS Glu298Asp genotype frequencies and serum nitric oxide levelssurrogate

In the Turkish population, coronary artery disease does not appear to be associated with alterations in eNOS Glu298Asp genotype frequency or serum nitric oxide levels.

Cite This Study

Afrasyap et al. (2004) studied this question.

synapsesocial.com/papers/6a7cd7953c7b3e4c163e138ehttps://doi.org/10.1093/abbs/36.10.661

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial Nitric Oxide Gene Polymorphism (Glu298Asp) Is not Associated with Coronary Artery Disease in Turkish Population2002 · 34 citations
  2. 2Reduced Plasma Concentrations of Nitrogen Oxide in Individuals With Essential Hypertension1997 · 157 citations
  3. 3Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene1993 · 877 citations
  4. 4Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease2001 · 124 citations
  5. 5A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK1999 · 531 citations