Heritability of Blood Pressure and Hemodynamics in African- and European-American Youth
Why the study?
Are there ethnic differences in the relative contribution of genes and environment to population variation in blood pressure and underlying hemodynamics between African-American and European-American youth?
Population
534 twin pairs, including monozygotic and dizygotic twins of the same and opposite sex, mean age 14.7+/-3.1…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Similar heritabilities across ethnic groups do not explain adult hypertension disparities; leaves open gene-environment interactions or later exposures.
Structured PICO
Are there ethnic differences in the relative contribution of genes and environment to population variation in blood pressure and underlying hemodynamics between African-American and European-American youth?
P
Population
534 twin pairs (308 European-American and 226 African-American), including monozygotic and dizygotic twins of the same and opposite sex, mean age 14.7+/-3.1 years.
O
Outcome
Heritability of resting blood pressure (systolic blood pressure, diastolic blood pressure, pulse pressure) and hemodynamics (stroke volume, cardiac index, total peripheral resistance index, heart rate)surrogate
Genetic and environmental contributions to blood pressure and hemodynamics are similar between African-American and European-American youth, suggesting that the higher prevalence of hypertension in African-Americans is not driven by differences in heritability.
Cite This Study
Snieder et al. (2003) studied this question.