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November 1, 1995American Journal of Hypertension

Effect of acute and chronic losartan therapy on active and inactive renin and active renin glycoforms*

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Why the study?

Does losartan alter plasma active and inactive renin and active renin glycoforms in essential hypertensive patients?

Population

11 essential hypertensive patients

Comparison

Losartan 50 mg single dose and monotherapy for… vs Pretreatment baseline

Design

Cohort

Follow-up

42 days

Authors

JOJohn A. OpsahlAlberta Hospital EdmontonMGMichael R. GoldbergAssaf Harofeh Medical CenterSKStephen A. KatzUniversity of Minnesota

Discussion

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Implication

No immediate change to losartan use in hypertension; leaves open clinical relevance of renin glycoform shifts.

Structured PICO

Does losartan alter plasma active and inactive renin and active renin glycoforms in essential hypertensive patients?

P
Population
11 essential hypertensive patients
I
Intervention
Losartan 50 mg single dose (acute) and monotherapy for 42 days (chronic)
C
Comparator
Pretreatment baseline
O
Outcome
Plasma active renin concentration (ARC), active renin glycoforms separated by isoelectric focusing, and inactive reninsurrogate

Acute and chronic losartan therapy increases circulating active renin concentration and alters the profile of circulating renin glycoforms in essential hypertensive patients.

Cite This Study

Opsahl et al. (1995) studied this question.

synapsesocial.com/papers/6a7cd87ae9867978b6a1e25dhttps://doi.org/10.1016/0895-7061(95)00232-e

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response of plasma prorenin and active renin to chronic and acute alterations of renin secretion in normal humans. Studies using a direct immunoradiometric assay.1989 · 86 citations
  2. 2Renin and Renin Inhibition in Anephric Man1993 · 7 citations
  3. 3Role of renin isoelectric heterogeneity in renal storage and secretion of renin.1993 · 12 citations
  4. 4Renal secretion and hepatic clearance of human multiple renin forms.1990 · 12 citations
  5. 5Modification of glycosylation of renin in sodium-depleted and captopril-treated rats1989 · 14 citations