Effect of right ventricular pacing lead site on left ventricular function in patients with high-grade atrioventricular block: results of the Protect-Pace study
Why the study?
Does right ventricular high septal pacing prevent left ventricular systolic dysfunction compared to right ventricular apical pacing in patients with high-grade AV block requiring >90% ventricular pacing?
Population
240 patients with high-grade AV block requiring >90% ventricular pacing and preserved baseline LVEF >50%…
Comparison
Right ventricular high septal (RVHS) pacing vs Right ventricular apical (RVA) pacing
Design
RCT, randomized
Follow-up
2 years
Authors
Discussion
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Member takes
Implication
High septal pacing confers no LVEF benefit over apical; challenges routine septal lead preference in high-grade AV block.
Structured PICO
Does right ventricular high septal pacing prevent left ventricular systolic dysfunction compared to right ventricular apical pacing in patients with high-grade AV block requiring >90% ventricular pacing?
P
Population
240 patients with high-grade AV block requiring >90% ventricular pacing and preserved baseline LVEF >50%, mean age 74 ± 11 years, 67% male, international.
I
Intervention
Right ventricular high septal (RVHS) pacing
C
Comparator
Right ventricular apical (RVA) pacing
O
Outcome
Change in left ventricular ejection fraction (LVEF) over a 2-year study periodsurrogate
In patients with high-grade AV block and preserved LVEF, right ventricular high septal pacing does not provide a protective effect on left ventricular function over right ventricular apical pacing at 2 years.
Cite This Study
Kaye et al. (2014) studied this question.