Key result
RVP linked to ~21% greater 6MWT distance vs. LVP without worsening LV function.
Why the study?
Pacing from the apex of the right ventricle is not optimal, and the effects of right ventricular versus left ventricular pacing on LV function and dyssynchrony needed assessment.
Does right ventricular apical pacing compared to left ventricular pacing affect LV function and dyssynchrony in patients with pacemaker indications?
Cohort (n=48)
No
Does right ventricular apical pacing compared to left ventricular pacing affect LV function and dyssynchrony in patients with pacemaker indications?
Absolute Event Rate: 540.5% vs 446.5%
p-value: p=0.015
Right ventricular apical pacing does not appear to have significant detrimental effects on LV synchrony and function, remaining a viable pacing site for patients with EF > 35%.
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May support right ventricular pacing for improved exercise capacity; leaves open confirmation in randomized trials.
Elkholy et al. (2022) conducted a cohort in Indications for permanent pacemaker implantation (e.g., sick sinus syndrome, complete heart block) (n=48). Right ventricular apical pacing vs. Left ventricular pacing was evaluated on 6-minute walk test (6-MWT) distance in meters (p=0.015). Right ventricular pacing resulted in a significantly longer 6-minute walk test distance compared to left ventricular pacing (540.5 vs 446.5 meters, p=0.015) without significant deterioration in left ventricular function.
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