Why the study?
Does atenolol, nitrendipine, or enalapril improve blood pressure response rates compared to hydrochlorothiazide in patients with mild to moderate hypertension?
Population
868 male and female outpatients, aged 21-70 years, with essential hypertension
Comparison
Atenolol, nitrendipine, or enalapril once or… vs Hydrochlorothiazide 12.5-25 mg once or twice…
Design
RCT, randomised, double blind
Follow-up
48 weeks
Authors
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Atenolol may be preferred initially for higher BP response rates in mild-moderate hypertension; challenges assumptions of superiority for newer antihypertensive classes.
Does atenolol, nitrendipine, or enalapril improve blood pressure response rates compared to hydrochlorothiazide in patients with mild to moderate hypertension?
Atenolol demonstrated a higher initial blood pressure response rate compared to enalapril, hydrochlorothiazide, and nitrendipine, with no evidence of superiority for the newer drug classes.
Anlauf et al. (1997) studied this question.
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