Why the study?
What is the incidence of adverse effects requiring drug discontinuation during long-term antihypertensive therapy in hypertensive patients?
Population
5,485 hypertensive persons who were not taking antihypertensive medications at the beginning of the study…
Design
Cohort
Follow-up
5 years
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Reassures on low severe adverse event rates with long-term antihypertensives; leaves open need for randomized confirmation in broader populations.
What is the incidence of adverse effects requiring drug discontinuation during long-term antihypertensive therapy in hypertensive patients?
Long-term antihypertensive therapy is relatively safe, with less than 10% of patients experiencing definite or probable side effects requiring drug discontinuation and severe adverse events being rare.
A 1985 study studied this question.
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