Why the study?
Are plasma GHBP levels lower in patients with IDDM compared to patients with NIDDM and nondiabetic controls?
Population
Patients with insulin-dependent diabetes mellitus, patients with non-insulin-dependent diabetes, and…
Design
Cross-sectional
Authors
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GHBP reduction in IDDM may signal GH resistance; leaves open receptor downregulation as mediator pending prospective studies.
Are plasma GHBP levels lower in patients with IDDM compared to patients with NIDDM and nondiabetic controls?
IDDM is associated with low GHBP levels, suggesting that the growth hormone resistance observed in this disorder may be mediated by a decrease in GH receptor levels.
Mercado et al. (1992) studied this question.
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