Population
Differentiated neurons acutely dissociated from juvenile guinea pig hippocampus and tissue-cultured neurons…
Comparison
Protein kinase C activators vs Control conditions or inactive phorbol esters
Design
Preclinical
Authors
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PKC effects on hippocampal ion currents remain preclinical; leaves open in vivo or translational relevance to human synaptic function.
PKC activators selectively regulate specific components of calcium and potassium currents directly on postsynaptic hippocampal neurons.
Doerner et al. (1988) studied this question.
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