Population
Human and rodent pancreas tissues, RINm5f insulinoma cell line, HEK293 cells, and pancreas tissues from…
Comparison
Cloning and expression of novel spliced variants… vs Original human BKβ2 or BK-channel α-subunit alone
Design
Preclinical
Authors
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BKβ2b may alter pancreatic channel properties vs BKβ2a; hypothesis-generating for insulin secretion regulation.
The predominant splicing of BKβ2b over BKβ2a alters BK channel properties and distribution, potentially modulating insulin secretion in pancreatic β-cells.
Ohya et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: