November 9, 2007Journal of Biological ChemistryOpen Access

Four-turn α-Helical Segment Prevents Surface Expression of the Auxiliary hβ2 Subunit of BK-type Channel

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Population

In vitro models studying the auxiliary hbeta2 subunit of BK-type channels

Design

Preclinical

Authors

CLCaixia LvHebei General Hospital MCMaorong ChenYunnan University GGGeliang GanYale University

Discussion

Member takes

Implication

May inform beta-subunit trafficking mechanisms; leaves open relevance to human cardiac channelopathies.

Structured PICO

Population

In vitro models studying the auxiliary hbeta2 subunit of BK-type channels

Intervention

Investigation of the N-terminal four-turn alpha helical segment of hbeta2

Outcome

Trafficking mechanism and surface expression of the hbeta2 subunitsurrogate

The study identifies a four-turn alpha helical segment at the N terminus of the hbeta2 subunit that acts as an endoplasmic reticulum retention signal, preventing its surface expression.

Cite This Study

Lv et al. (2007) studied this question.

synapsesocial.com/papers/6a7d0bcdfac401f278424eac https://doi.org/10.1074/jbc.m704440200

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Four-turn α-Helical Segment Prevents Surface Expression of the Auxiliary hβ2 Subunit of BK-type Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Four-turn α-Helical Segment Prevents Surface Expression of the Auxiliary hβ2 Subunit of BK-type Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider