Why the study?
Impaired myocardial energy homeostasis contributes to HFpEF pathophysiology, and it was unknown whether trimetazidine could improve myocardial energy homeostasis and exercise haemodynamics.
Does trimetazidine improve pulmonary capillary wedge pressure during exercise in patients with HFpEF?
Does trimetazidine improve pulmonary capillary wedge pressure during exercise in patients with HFpEF?
Trimetazidine does not improve exercise hemodynamics or myocardial energy homeostasis in patients with HFpEF.
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Trimetazidine offers no benefit in HFpEF; challenges metabolic modulation of energy homeostasis as a therapeutic strategy.
Bovenkamp et al. (2023) studied this question.
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