What question did this study set out to answer?

To compare three arterial compliance techniques against clinic blood pressures and the cardiac time-tension integral to determine their utility in assessing cardiac load.

December 1, 2001HypertensionOpen Access

Office Blood Pressures, Arterial Compliance Characteristics, and Estimated Cardiac Load

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Why the study?

Do compliance-related variables provide an advantage over cuff blood pressure in estimating cardiac work in hypertensive and normotensive subjects?

Population

91 subjects, comprising 63 established hypertensive and 28 age-matched normotensive subjects

Comparison

Measurement of arterial stiffness using 3… vs Clinic blood pressures and cardiac time-tension…

Design

Cross-sectional

Authors

JIJoseph L. IzzoGeneral / Preventive / Lipids TMTimothy S. ManningNaval Sea Systems Command BSBarbara E. ShykoffDayton VA Medical Center

Discussion

Member takes

Implication

Cuff BP suffices for estimating cardiac work; challenges incremental utility of compliance measures and leaves open prospective validation.

Key Points

To compare three arterial compliance techniques against clinic blood pressures and the cardiac time-tension integral to determine their utility in assessing cardiac load.
Evaluated 63 patients with established hypertension and 28 age-matched normotensive individuals in the sitting position.
Measured arterial stiffness using systolic pulse contour analysis, diastolic pulse contour analysis via a modified Windkessel model, and muscular brachial artery compliance via cuff plethysmography.
Assessed correlations between compliance variables, routine clinic blood pressure indices, and the cardiac time-tension integral (CTTI).
CTTI correlated strongly with systolic blood pressure (r=0.81), integrated mean arterial pressure (r=0.83), and systolic pressure-heart rate product (r=0.85), but less with diastolic pressure (r=0.71) or pulse pressure (r=0.57).
Hypertensive subjects showed marginal reductions in large vessel compliance (C1) and higher central systolic augmentation, while muscular artery compliance trended higher and small artery compliance (C2) showed no difference between groups.
Compliance-related parameters correlated weakly with CTTI and exhibited weak or absent correlations among themselves.

Structured PICO

Do compliance-related variables provide an advantage over cuff blood pressure in estimating cardiac work in hypertensive and normotensive subjects?

Population

91 subjects, comprising 63 established hypertensive and 28 age-matched normotensive subjects

Intervention

Measurement of arterial stiffness using 3 compliance-related techniques: systolic pulse contour analysis, diastolic pulse contour analysis (modified Windkessel model), and muscular (brachial) artery compliance by cuff plethysmography

Comparator

Clinic blood pressures and cardiac time-tension integral (CTTI)

Outcome

Correlations between compliance-related variables, clinic blood pressures, and cardiac time-tension integral (CTTI)surrogate

Compliance-related variables provide little additional advantage over standard cuff blood pressure in the office estimation of cardiac work.

Limitations

Theoretical methodological weaknesses
Measurement artifacts
Intrinsic hemodynamic differences of the sitting position

Cite This Study

Izzo et al. (2001) studied this question.

synapsesocial.com/papers/6a7d17593575152c8237cf03 https://doi.org/10.1161/hy1201.097922

Topics

Hypertension management

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Implication

Cuff BP suffices for estimating cardiac work; challenges incremental utility of compliance measures and leaves open prospective validation.

Office Blood Pressures, Arterial Compliance Characteristics, and Estimated Cardiac Load

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Office Blood Pressures, Arterial Compliance Characteristics, and Estimated Cardiac Load

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider