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March 9, 2010European Heart JournalOpen Access

Substrate and Trigger Ablation for Reduction of Atrial Fibrillation (STAR AF): a randomized, multicentre, international trial

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Why the study?

Does combined PVI + CFE ablation improve freedom from AF compared to PVI or CFE alone in patients with high-burden paroxysmal or persistent AF?

Population

100 patients with drug-refractory, high-burden paroxysmal or persistent atrial fibrillation, age 57 +/- 10…

Comparison

Combined pulmonary vein isolation and complex… vs PVI alone (n=32) or CFE alone (n=34)

Design

RCT, randomized to one of three arms

Follow-up

1 year

Authors

RMR. MantovanLMLaurent MacleGMGiuseppe Martino

Discussion

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Overview

Supports combined PVI + CFE for higher single-procedure AF freedom; extends prior ablation strategies with RCT confirmation.

Structured PICO

Does combined PVI + CFE ablation improve freedom from AF compared to PVI or CFE alone in patients with high-burden paroxysmal or persistent AF?

P
Population
100 patients with drug-refractory, high-burden paroxysmal (episodes >6 h, >4 in 6 months) or persistent atrial fibrillation (AF), age 57 +/- 10 years, 35% persistent AF, enrolled at eight international centres.
I
Intervention
Combined pulmonary vein isolation (PVI) and complex fractionated electrogram (CFE) ablation (n=34)
C
Comparator
PVI alone (n=32) or CFE alone (n=34)
O
Outcome
Freedom from AF >30 s at 1 yearsurrogate

In patients with high-burden paroxysmal or persistent AF, combined PVI and CFE ablation significantly increases freedom from AF at 1 year compared to PVI or CFE alone.

Cite This Study

Mantovan et al. (2010) studied this question.

synapsesocial.com/papers/6a7d20cff1daba58ecd5a5ffhttps://doi.org/10.1093/eurheartj/ehq041
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