HRV and MIBG measures may not change proportionally to the severity of cardiac autonomic dysfunction in congestive heart failure.
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HRV-MIBG correlations absent within CHF; hypothesis-generating for non-proportional autonomic marker changes with disease severity.
It is assumed that the low-frequency power (LF) of heart rate variability (HRV) increases with progress of congestive heart failure (CHF), therefore positively correlating with cardiac 123I-metaiodobenzylguanidine (MIBG) washout. It is demonstrated here that HRV, including normalized LF, correlated inversely with MIBG washout and positively with the ratio of heart-to-mediastinum MIBG activity in controls and CHF patients, whereas these correlations were not observed within CHF patients. Thus MIBG washout may increase and HRV including normalized LF may decrease with CHF, although the HRV and MIBG measures may not similarly change in proportion to the severity of the cardiac autonomic dysfunction in CHF.
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Kurata et al. (1998) studied this question.
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