April 1, 1988Journal of Hypertension
Blood pressure and endogenous testosterone in men
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Discussion
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Implication
Population study reveals lower endogenous testosterone levels correlate with higher blood pressure in men, indicating hormonal involvement in blood pressure regulation.
Key Points
- To evaluate the association between endogenous sex hormone levels and blood pressure in adult men.
- Analyzed cross-sectional data from N=1132 men aged 30–79 years participating in the Rancho Bernardo population study.
- Assessed systolic and diastolic blood pressure alongside circulating levels of testosterone, androstenedione, estrone, estradiol, and sex hormone-binding globulin, adjusting for age and body mass index.
- Men with hypertension had significantly lower testosterone levels than non-hypertensive men, showing an inverse correlation with systolic (r = 0.17, P < 0.001) and diastolic blood pressure (r = −0.15, P < 0.001).
- A stepwise decrease in mean systolic and diastolic blood pressure was observed across increasing quartiles of testosterone, which remained apparent after adjusting for age and body mass index.
- No consistent associations were observed between blood pressure and androstenedione, estrone, estradiol, or sex hormone-binding globulin.
Cite This Study
Khaw et al. (1988) studied this question.