Isolation and near-complete genome of human enterovirus B4 (Coxsackie virus B4) strain isolated from a nasopharyngeal swab of a 5-year-old male child with severe hand, foot, and mouth disease in Mizoram, India

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  Fig 1. Multiple sequence alignment was performed using MAFFT version 7.526 with default parameters (11). ML phylogenetic tree of Coxsackievirus B4 (CVB4) was constructed based on the VP1 gene. The tree was inferred using IQ-TREE (version 2.0.7) (12) with the best-fit substitution model and 1,000 bootstrap replicates. Bootstrap values are shown at the corresponding branches. The tree was visualized using FigTree (http://tree.bio.ed.ac.uk/software/figtree/). Sequences are color-coded according to previously reported genotypes (A: black, B: pink, D: green, E: blue, G: gray, and F: brown). The CVB4 isolate from India is highlighted with a red circle.