Population
Human embryonic stem cell-derived cardiomyocytes
Comparison
In vitro differentiation over a 3-month period vs Undifferentiated human embryonic stem cells
Design
Preclinical
Follow-up
3 months
Authors
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Supports extended in vitro differentiation for more mature cardiomyocytes in research models; leaves open clinical translation to cardiac repair.
Human embryonic stem cell-derived cardiomyocytes undergo functional and molecular electrophysiological maturation over 3 months in vitro, approaching an adult phenotype.
Sartiani et al. (2007) studied this question.
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