Why the study?
The long-term impact of early intravenous metoprolol in STEMI patients on left ventricular strain using feature-tracking CMR, and its association with prognosis, had not been established.
Does early intravenous metoprolol before primary percutaneous coronary intervention reduce major adverse cardiac events at 5 years in patients with first anterior STEMI?
Population
270 patients with first anterior STEMI
Comparison
Up to 15 mg intravenous metoprolol before primary PCI vs conventional STEMI therapy
Design
Randomized clinical trial
Follow-up
5 years
Authors
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Supports early IV metoprolol before primary PCI in anterior STEMI; extends RCT evidence to long-term outcomes.
Does early intravenous metoprolol before primary percutaneous coronary intervention reduce major adverse cardiac events at 5 years in patients with first anterior STEMI?
Early intravenous metoprolol before primary PCI in anterior STEMI provides long-term prognostic benefits, and LV global longitudinal strain assessed by CMR offers incremental risk stratification value.
Podlesnikar et al. (2020) studied this question.
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