August 11, 2016Critical Care MedicineOpen Access

Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats

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Population

Infant, juvenile, adult, and elderly male RCCHan Wistar rats.

Comparison

Intratracheal administration of… vs Comparison across different age groups.

Design

Preclinical, randomized

Follow-up

4 hours

Authors

LSLaura R. A. SchoutenApple (Israel)HHHendrik J. F. HelmerhorstLeiden University GWGerry T. M. WagenaarTissue Dynamics (Israel)

Discussion

Member takes

Implication

May heighten lung injury risk with aging; leaves open renin-angiotensin modulation in elderly ARDS.

Structured PICO

Population

Infant (15 ± 2 d), juvenile (37 ± 2 d), adult (4 ± 0.2 mo), and elderly (19.5 ± 0.5 mo) male RCCHan Wistar rats.

Intervention

Intratracheal administration of lipopolysaccharide (5 mg/kg) and 4 hours of mechanical ventilation (15 mL/kg) to induce acute lung injury.

Comparator

Comparison across different age groups (infant vs juvenile vs adult vs elderly).

Outcome

Angiotensin-converting enzyme (ACE) and ACE2 activity in bronchoalveolar lavage fluid, membrane-bound ACE activity, inflammatory mediator response, and lung injury severity (wet-to-dry ratio and histology).surrogate

Increasing age in a rat model of acute lung injury is associated with an imbalance in the pulmonary renin-angiotensin system, leading to aggravated inflammation and more severe lung injury.

Cite This Study

Schouten et al. (2016) studied this question.

synapsesocial.com/papers/6a7d545b149bd8e2c5749d89 https://doi.org/10.1097/ccm.0000000000002008

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