Why the study?
Despite treatment guidance endorsing shortened DAPT duration in high bleeding risk patients after drug-eluting stents, limited evidence exists to support these recommendations.
Does 1-month DAPT followed by SAPT provide safe and effective outcomes in high bleeding risk patients undergoing PCI with zotarolimus-eluting stents?
Does 1-month DAPT followed by SAPT provide safe and effective outcomes in high bleeding risk patients undergoing PCI with zotarolimus-eluting stents?
A 1-month DAPT strategy followed by SAPT in high bleeding risk patients undergoing PCI with zotarolimus-eluting stents met the prespecified performance goal for cardiac death or MI between 1 month and 1 year.
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Supports 1-month DAPT in high-bleeding-risk PCI; leaves open randomized confirmation before practice change.
Kandzari et al. (2020) studied this question.
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