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March 6, 1979Biochemistry

Cyclic adenosine monophosphate dependent and independent phosphorylation of sarcolemma membrane proteins in perfused rat heart

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Population

Perfused rat heart model

Design

Preclinical

Authors

DWDonal A. WalshUniversity of IowaMCMark S. ClippingerSSS. SivaramakrishnanRajiv Gandhi Centre for Biotechnology

Discussion

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Implication

Findings in rat hearts warrant caution before human extrapolation; leaves open the 27 kDa protein's role in catecholamine signaling.

Structured PICO

P
Population
Perfused rat heart model
I
Intervention
Epinephrine
O
Outcome
Phosphorylation of sarcolemma membrane proteins (A protein [36,000 MW] and B protein [27,000 MW])surrogate

Epinephrine induces cAMP-dependent phosphorylation of a 27 kDa sarcolemma protein in perfused rat hearts, though this does not appear coordinated with its inotropic effect.

Cite This Study

Walsh et al. (1979) studied this question.

synapsesocial.com/papers/6a7d5d5db358a2e04383d1bdhttps://doi.org/10.1021/bi00572a021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adenosine 3′:5′-Monophosphate-dependent Protein Kinase-catalyzed Phosphorylation Reaction and Its Relationship to Calcium Transport in Cardiac Sarcoplasmic Reticulum1974 · 383 citations
  2. 2Stimulation of calcium accumulation in cardiac sarcolemma by protein kinase1976 · 86 citations
  3. 3Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart1976 · 190 citations
  4. 4Phosphorylation of the inhibitory subunit of troponin in perfused hearts of mice deficient in phosphorylase kinase. Evidence for the phosphorylation of troponin by adenosine 3′:5′-phosphate-dependent protein kinase <i>in vivo</i>1977 · 25 citations
  5. 5Catalysis of the Phosphorylase Kinase Activation Reaction1971 · 294 citations