Why the study?
Does human insulin affect sleep and sleep EEG differently than porcine insulin in patients with insulin-dependent diabetes mellitus?
Population
8 patients with insulin-dependent diabetes mellitus (IDDM)
Comparison
Human insulin vs Porcine insulin
Design
Open-label (subjects were not blinded)
Follow-up
3 separate sessions of 2 consecutive nights
Authors
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Human insulin may alter sleep spindle EEG power differently than porcine; hypothesis-generating for thalamocortical effects, needs confirmation before any practice relevance.
Does human insulin affect sleep and sleep EEG differently than porcine insulin in patients with insulin-dependent diabetes mellitus?
Human insulin may affect brain functions, specifically spindle-generating mechanisms in the thalamocortical system, differently than porcine insulin under near-normoglycemic conditions.
Roth et al. (1998) studied this question.
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