Key result
Human insulin and porcine insulin produced similar maximal hypoglycaemic increments in muscle sympathetic nerve activity in healthy subjects (15 vs 15 bursts/min; P=NS).
Why the study?
Does human insulin compared to porcine insulin alter muscle sympathetic nerve activity during euglycaemia or hypoglycaemia in healthy subjects?
Population
9 healthy subjects
Comparison
Human insulin administered during a low dose… vs Porcine insulin administered in the same manner
Design
RCT, double blind
Authors
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Human and porcine insulin elicit equivalent hypoglycaemic sympathetic activation; confirms interchangeability for this response in healthy subjects.
RCT (n=9)
Double-blind
crossover
Does human insulin compared to porcine insulin alter muscle sympathetic nerve activity during euglycaemia or hypoglycaemia in healthy subjects?
Absolute Event Rate: 15% vs 15%
p-value: p=NS
Human and porcine insulin elicit similar sympathetic, cardiovascular, and hormonal responses during euglycaemia and hypoglycaemia in healthy subjects.
Frandsen et al. (1996) conducted an RCT in Healthy (n=9). Human insulin vs. Porcine insulin was evaluated on Maximal hypoglycaemic increments of muscle sympathetic nerve activity (MSNA) (p=NS). Human insulin and porcine insulin produced similar maximal hypoglycaemic increments in muscle sympathetic nerve activity in healthy subjects (15 vs 15 bursts/min; P=NS).
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