What question did this study set out to answer?

To determine whether hyperventilation-induced hypocapnia and circulatory delay act as primary drivers of Cheyne-Stokes respiration with central sleep apnea in congestive heart failure.

August 1, 1993American Review of Respiratory Disease

Role of Hyperventilation in the Pathogenesis of Central Sleep Apneas in Patients with Congestive Heart Failure

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Why the study?

Is hypocapnia associated with Cheyne-Stokes respiration with central sleep apnea in patients with congestive heart failure?

Population

24 male patients with congestive heart failure (CHF)

Design

Cross-sectional

Follow-up

overnight

Authors

MNMatthew T. NaughtonThe Alfred Hospital DBDean BenardMount Sinai Hospital ATAmy TamHarvard University

Discussion

Member takes

Implication

Hypocapnia may contribute to CSR-CSA in HF; leaves open causal role and need for prospective confirmation.

Key Points

To determine whether hyperventilation-induced hypocapnia and circulatory delay act as primary drivers of Cheyne-Stokes respiration with central sleep apnea in congestive heart failure.
Assessed 24 male patients with congestive heart failure who underwent overnight polysomnography to measure transcutaneous PCO2, arterial blood gases, and lung to ear circulation time.
Categorized participants into a CSR-CSA group (n = 12; 49.2 ± 6.3 events/h) and a non-CSR-CSA control group (n = 12; 4.9 ± 0.8 events/h).
Awake PaCO2 (33.0 ± 1.2 vs. 37.5 ± 1.0 mm Hg, p < 0.01) and mean nocturnal transcutaneous PCO2 (33.2 ± 1.2 vs. 42.5 ± 1.2 mm Hg, p < 0.0001) were significantly lower in the CSR-CSA group than controls.
Left ventricular ejection fraction, awake PaO2, mean nocturnal SaO2, and baseline lung to ear circulation time showed no significant differences between groups.
CSR-CSA cycle length was strongly correlated with lung to ear circulation time (r = 0.939, p < 0.001).

Structured PICO

Is hypocapnia associated with Cheyne-Stokes respiration with central sleep apnea in patients with congestive heart failure?

Population

24 male patients with congestive heart failure (CHF)

Comparator

CHF patients without Cheyne-Stokes respiration with central sleep apnea (CSR-CSA)

Outcome

Awake PaCO2 and mean sleep transcutaneous PCO2 (PtcCO2)surrogate

Hypocapnia and circulatory delay are important determinants of Cheyne-Stokes respiration with central sleep apnea and its cycle length in patients with congestive heart failure.

Cite This Study

Naughton et al. (1993) studied this question.

synapsesocial.com/papers/6a7d652700c5c9efbcaa1da4 https://doi.org/10.1164/ajrccm/148.2.330

Topics

Heart failure HFrEF treatment

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Role of Hyperventilation in the Pathogenesis of Central Sleep Apneas in Patients with Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Role of Hyperventilation in the Pathogenesis of Central Sleep Apneas in Patients with Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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