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January 29, 2013Circulation

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

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Why the study?

Does VEGF-angiopoietin-1 (VA1) improve ischemic limb perfusion with fewer side effects compared to VEGF in a mouse model?

Population

Mouse skeletal muscle (ischemic limb model)

Comparison

VEGF-angiopoietin-1 (VA1) transgene delivery vs VEGF (vascular endothelial growth factor)

Design

Preclinical

Authors

AAAndrey AnisimovUniversity of HelsinkiDTDenis TvorogovCentre for Cancer BiologyAAAnnamari AlitaloETH Zurich

Discussion

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Implication

VA1 merits further development for safer angiogenesis in ischemia; leaves open clinical translation to human peripheral artery disease.

Structured PICO

Does VEGF-angiopoietin-1 (VA1) improve ischemic limb perfusion with fewer side effects compared to VEGF in a mouse model?

P
Population
Mouse skeletal muscle (ischemic limb model)
I
Intervention
VEGF-angiopoietin-1 (VA1) transgene delivery
C
Comparator
VEGF (vascular endothelial growth factor)
O
Outcome
Blood flow, angiogenesis, and ischemic limb perfusionsurrogate

The VEGF-angiopoietin-1 chimera promotes effective therapeutic angiogenesis with reduced vessel leakiness and inflammation compared to VEGF in a preclinical model.

Cite This Study

Anisimov et al. (2013) studied this question.

synapsesocial.com/papers/6a7d67fde9ddcd9870aa1ee5https://doi.org/10.1161/circulationaha.112.127472
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Also Consider

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  1. 1Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation2010 · 150 citations
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  4. 4Angiopoietin-Related Growth Factor Enhances Blood Flow Via Activation of the ERK1/2-eNOS-NO Pathway in a Mouse Hind-Limb Ischemia Model2008 · 65 citations
  5. 5VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration2003 · 240 citations