June 1, 1983Journal of HygieneOpen Access

Antibody capture radioimmunoassay (MACRIA) for coxsackievirus B4 and B5-specific IgM

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Population

Sera samples including 100 antenatal sera, cases of CBV4 and CBV5 infection, other CBV infections…

Design

Other

Authors

PMP Morgan-CapnerUniversity of Leicester CMC. McSorleyKing's College London

Discussion

Member takes

Implication

Cross-reactivity precludes type-specific diagnosis with CBV4/5-IgM assays; leaves open development of more specific enterovirus serology.

Structured PICO

Population

Sera samples including 100 antenatal sera, cases of CBV4 and CBV5 infection, other CBV infections, echovirus/coxsackievirus A infections, rheumatoid factor containing sera, and sera from other infections.

Intervention

Antibody capture radioimmunoassay (MACRIA) using unrefined coxsackievirus B (CBV) antigen

Outcome

Detection of coxsackievirus B4 and B5-specific IgM and assessment of assay specificity and cross-reactivitysurrogate

The developed MACRIA for coxsackievirus B4 and B5-specific IgM can detect enterovirus infections but lacks type-specificity due to significant cross-reactivity.

Limitations

Relatively insensitive assay due to high cutoff required to exclude low-level reactivity from remote infections
High cross-reactivity with other enteroviruses

Cite This Study

Morgan-Capner et al. (1983) studied this question.

synapsesocial.com/papers/6a7d6c51e9ddcd9870aa2003 https://doi.org/10.1017/s0022172400028977

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Antibody capture radioimmunoassay (MACRIA) for coxsackievirus B4 and B5-specific IgM

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Antibody capture radioimmunoassay (MACRIA) for coxsackievirus B4 and B5-specific IgM

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider