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August 13, 2026Open Access

Formulation and Evaluation of Ciprofloxacin Nanosuspension for Oral Drug Delivery: A Comprehensive Review

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Review outlines nanosuspensions' impact on ciprofloxacin's bioavailability in drug delivery, suggesting key advancements.

This review aims to explore the formulation and evaluation of ciprofloxacin nanosuspensions to enhance oral delivery effectiveness.
Comprehensive overview of formulation techniques including media milling, high-pressure homogenization, nanoprecipitation, and ultrasonication.
Discussion on the use of stabilizers like Poloxamer 188, PVP K30, HPMC, and Tween 80 in enhancing formulation stability.
Summary of characterization parameters including particle size, zeta potential, and dissolution behavior.
Nanosuspensions demonstrated improved dissolution characteristics and bioavailability of ciprofloxacin compared to conventional formulations.
Improvements in therapeutic efficacy were noted, indicating a successful enhancement of drug performance.
Challenges include large-scale manufacturing and regulatory hurdles despite positive outcomes.

Hariharaputhraayyanar2 Karthick S.1* (2026) studied this question.

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