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Evaluate the role of IL1R2⁺ inflammatory monocytes in immune dysregulation and mortality prediction in COVID-19.

August 13, 2026Shock

IL1R2⁺ Inflammatory Monocytes Contribute to Immune Dysregulation and Predict Mortality in COVID-19

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Randomized trial shows IL1R2 levels predict mortality in COVID-19, suggesting its role as a therapeutic target.

Evaluate the role of IL1R2⁺ inflammatory monocytes in immune dysregulation and mortality prediction in COVID-19.
Analyzed publicly available single-cell RNA sequencing (scRNA-seq) dataset of peripheral blood mononuclear cells from COVID-19 patients (GSE149689).
assessed an independent monocyte transcriptomic dataset (GSE198256) to evaluate IL1R2 dynamics during COVID-19 and recovery.
Measured serum IL1R2 levels in COVID-19 patients and healthy controls, correlating with disease severity and mortality.
IL1R2 was primarily expressed in monocytes from COVID-19 patients, increasing during active infection and decreasing post-recovery.
IL1R2⁺ monocytes showed heightened inflammation-associated pathways including TNFα/NF-κB and IL6-JAK-STAT3, with active signaling networks identified.
Serum IL1R2 levels correlated with patient mortality, showing predictive performance comparable to procalcitonin and D-dimer.

Yang et al. (2026) studied this question.

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