What question did this study set out to answer?

To characterize the organ-specific expression dynamics of IL-1 receptors during sepsis.

Decoding IL-1 receptor 1 and 2 expression profiles across organs in sepsis

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Analysis reveals distinct IL-1 receptor expression in neutrophils and macrophages during sepsis, indicating immune modulation.

To characterize the organ-specific expression dynamics of IL-1 receptors during sepsis.
Used single-cell RNA sequencing datasets
Validated findings with flow cytometry
Analyzed data across organs like lung, liver, heart, and small intestine
IL-1R1 primarily expressed on non-immune cells such as lung fibroblasts
IL-1R2 upregulated on neutrophils and monocyte-derived macrophages in sepsis
Resident macrophages like alveolar and Kupffer cells maintain low IL-1R2 expression during sepsis

Tan et al. (2025) studied this question.

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