Quinidine inhibits calcium transport and Ca(++)-activated ATPase activity in both skeletal and cardiac sarcoplasmic reticulum, providing a mechanistic explanation for its differential effects on muscle contractility.
No takes yet. Share an insight, caveat, or question.
No clinical change warranted from animal data; leaves open translation of SR effects to human contractility.
Fuchs et al. (1968) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: