Key result
Quinidine and caffeine released substantially more calcium from cardiac sarcoplasmic reticulum (27.7% and 34.3%, respectively) than from skeletal sarcoplasmic reticulum (4.1% and 10.5%).
Caffeine and quinidine induce greater calcium release from cardiac sarcoplasmic reticulum than from skeletal sarcoplasmic reticulum, suggesting mechanisms for their effects on muscle contractility.
No takes yet. Share an insight, caveat, or question.
Differential effects may underlie tissue-specific actions; hypothesis-generating for human cardiac contractility and requires further study.
William R. Thorpe (1973) studied this question. Caffeine and Quinidine was evaluated on Release of actively bound calcium. Quinidine and caffeine released substantially more calcium from cardiac sarcoplasmic reticulum (27.7% and 34.3%, respectively) than from skeletal sarcoplasmic reticulum (4.1% and 10.5%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: