Key result
Self-gated cardiac MRI at 11.7 T demonstrated excellent reproducibility of global LV function parameters over 360 days in mice, with no significant variations for EDV, ESV, SV, and EF.
Observational (n=5)
Self-gated CINE MRI at 11.7 T provides highly reproducible longitudinal assessment of left ventricular function in mice over 360 days.
Enables reliable long-term LV phenotyping in mice; leaves open clinical translation of high-field self-gated MRI.
= 5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters.
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Zuo et al. (2017) reported an observational. Self-gated CINE MRI was evaluated on Reproducibility of global LV function parameters. Self-gated cardiac MRI at 11.7 T demonstrated excellent reproducibility of global LV function parameters over 360 days in mice, with no significant variations for EDV, ESV, SV, and EF.
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