Population
Cardiac ryanodine receptors (RyR) in an in vitro model
Design
Preclinical
Authors
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Sorcin inhibition of RyR may modulate calcium handling; leaves open any role in arrhythmia or heart failure therapies.
Sorcin modulates cardiac ryanodine receptor function by inhibiting its open probability, an effect that is decreased by protein kinase A phosphorylation.
Lokuta et al. (1997) studied this question.
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