Key result
A high-salt diet (4%) over 3 weeks promoted progressive kidney injury, measured by increased proteinuria and fibrosis, in young female Ren2 rats compared to controls.
Population
Young female transgenic (mRen2)27 (Ren2) rats and Sprague-Dawley (SD) littermates
Comparison
High-salt diet (4%) over 3 weeks vs Sprague-Dawley and Ren2 controls
Design
Preclinical
Follow-up
3 weeks
Authors
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High-salt exposure should not alter clinical recommendations; leaves open TGF-β–mediated fibrosis mechanisms in human cardiorenal disease.
A high-salt diet promotes progressive kidney injury via fibrosis and TGF-β in a female rat model of excess tissue Ang II and circulating aldosterone.
Habibi et al. (2014) studied Kidney injury. High-salt diet vs. SD and Ren2 controls was evaluated on Proteinuria and fibrosis. A high-salt diet (4%) over 3 weeks promoted progressive kidney injury, measured by increased proteinuria and fibrosis, in young female Ren2 rats compared to controls.
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